Injectable Coformulations in Diabetology
نویسندگان
چکیده
Coformulations are a novel pharmaceutical development in diabetology. They are composed of two medicinal products, both of which maintain their distinct pharmacokinetic and pharmacodynamic properties. Currently available coformulations include combinations of basal and rapid-acting insulin, and basal and glucagon-like peptide 1 receptor agonists (GLP1RA). This review describes three coformulations which are in advanced stages of development, or are approved in certain markets. We discuss the basic and clinical pharmacology of these drugs, while describing clinical usage of the commercially available insulin degludec aspart (IDegAsp).
منابع مشابه
Erratum to: Injectable Coformulations in Diabetology
The second paragraph beginning on page 2 reads: In this review, we define injectable pharmaceutical coformulations as preparations, and which also maintain their distinct pharmacological properties. These are distinct from the pre-mixed insulins that have been available over the last 50 years (Table 1). It should instead read: In this review, we define injectable pharmaceutical coformulations a...
متن کاملChallenges for the pharmaceutical technical development of protein coformulations.
OBJECTIVES This review discusses challenges to stability, analytics and manufacturing of protein coformulations. Furthermore, general considerations to be taken into account for the pharmaceutical development of coformulated protein drug products are highlighted. KEY FINDINGS Coformulation of two or more active substances in one single dosage form has recently seen increasing use offering sev...
متن کاملBackground: New antiretroviral (ARV) drugs and improved formulations and coformulations of existing ARVs are actively promoted to diminish a patient’s pill burden and to minimise the opportunity for mismatched dosing,
Background: New antiretroviral (ARV) drugs and improved formulations and coformulations of existing ARVs are actively promoted to diminish a patient’s pill burden and to minimise the opportunity for mismatched dosing, although the effect of these advances is poorly understood. We determine how these changes affect the total daily pill burden (TDPB) for ARV and other drug use over a 20-year peri...
متن کاملFood choices during Ramadan
Few studies have assessed the dietary Practices of people with diabetes during Ramadan (1). A sub study of Ramadan prospective diabetes study (2) which was conducted at the outpatient department of Baqai Institute of Diabetology and endocrinology, Karachi Pakistan in 2009 analyzed the food choices of patients with diabetes during Ramadan. Several irregularities regarding dietary intake and food...
متن کاملInjectable Hydrogels: A Review of Injectability Mechanisms and Biomedical Applications
Hydrogels have been used for biomedical applications in recent decades. They are a perfect candidate for regenerative medicine as they resemble the extracellular matrix of native tissues. In addition, their highly hydrated structure makes them a suitable choice for drug and other therapeutics delivery. Injectable hydrogels have increasingly gained attention due to their capability for homogeneo...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره 6 شماره
صفحات -
تاریخ انتشار 2015